A Comprehensive Review on the Role of Obesity in Functional Cognition (Part III): Risk Factors and Studying Challenges
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Published
Sep 30, 2023
Abstract
Gaining a comprehensive understanding of the risk factors, devising efficacious therapies, and tackling the methodological obstacles inherent in investigating the cognitive consequences of obesity are imperative undertakings in both clinical and research contexts. The complex interaction between metabolic, inflammatory, and lifestyle factors highlights the necessity of adopting a holistic strategy to address cognitive impairments in patients with obesity. The resolution of methodological obstacles, including ethical concerns and the identification of suitable evaluation instruments, is crucial for the progression of our understanding in this domain and the enhancement of cognitive well-being among individuals impacted by obesity.
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Keywords
Obesity, Cognition, Risk Factors, Interventions, Challenges
References
1. Vidyanti AN, Hardhantyo M, Wiratama BS, Prodjohardjono A, Hu CJ. Obesity is less frequently associated with cognitive impairment in elderly individuals: A cross-sectional study in Yogyakarta, Indonesia. Nutrients 2020; 12(2):367. DOI: https://doi.org/10.3390/nu12020367
2. Wadden TA, Tronieri JS, Butryn ML. Lifestyle modification approaches for the treatment of obesity in adults. Am Psychol 2020; 75(2):235-251. DOI: https://doi.org/10.1037/amp0000517
3. Favieri F, Forte G, Casagrande M. The executive functions in overweight and obesity: A systematic review of neuropsychological cross-sectional and longitudinal studies. Front Psychol 2019; 10:2126. DOI: https://doi.org/10.3389/fpsyg.2019.02126
4. van den Brink AC, Brouwer-Brolsma EM, Berendsen AAM, van de Rest O. The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diets are associated with less cognitive decline and a lower risk of Alzheimer's Disease - A review. Adv Nutr 2019; 10(6):1040-1065. DOI: https://doi.org/10.1093/advances/nmz054
5. Di Liegro CM, Schiera G, Proia P, Di Liegro I. Physical activity and brain health. Genes (Basel) 2019; 10(9):720. DOI: https://doi.org/10.3390/genes10090720
6. Institute of Medicine (US) Subcommittee on Military Weight Management. Weight Management: State of the Science and Opportunities for Military Programs. Washington (DC): National Academies Press (US); 2004. 4, Weight-Loss and Maintenance Strategies. Available at: https://www.ncbi.nlm.nih.gov/books/NBK221839/
7. Lindström J, Louheranta A, Mannelin M, Rastas M, Salminen V, Eriksson J, Uusitupa M, Tuomilehto J; Finnish Diabetes Prevention Study Group. The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity. Diabetes Care 2003; 26(12):3230-3236. DOI: https://doi.org/10.2337/diacare.26.12.3230
8. Sindi S, Calov E, Fokkens J, Ngandu T, Soininen H, Tuomilehto J, Kivipelto M. The CAIDE Dementia Risk Score App: The development of an evidence-based mobile application to predict the risk of dementia. Alzheimers Dement (Amst) 2015; 1(3):328-333. DOI: https://doi.org/10.1016/j.dadm.2015.06.005
9. Diabetes Prevention Program (DPP) Research Group. The Diabetes Prevention Program (DPP): Description of lifestyle intervention. Diabetes Care 2002; 25(12):2165-2171. DOI: https://doi.org/10.2337/diacare.25.12.2165
10. Kivipelto M, Solomon A, Ahtiluoto S, Ngandu T, Lehtisalo J, Antikainen R, Bäckman L, Hänninen T, Jula A, Laatikainen T, Lindström J, Mangialasche F, Nissinen A, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): Study design and progress. Alzheimers Dement 2013; 9(6):657-665. DOI: https://doi.org/10.1016/j.jalz.2012.09.012
11. Liu X, Morris MC, Dhana K, Ventrelle J, Johnson K, Bishop L, Hollings CS, Boulin A, Laranjo N, Stubbs BJ, Reilly X, Carey VJ, Wang Y, Furtado JD, Marcovina SM, Tangney C, Aggarwal NT, Arfanakis K, Sacks FM, Barnes LL. Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) study: Rationale, design and baseline characteristics of a randomized control trial of the MIND diet on cognitive decline. Contemp Clin Trials 2021; 102:106270. DOI: https://doi.org/10.1016/j.cct.2021.106270
12. Calcaterra V, Verduci E, Milanta C, Agostinelli M, Todisco CF, Bona F, Dolor J, La Mendola A, Tosi M, Zuccotti G. Micronutrient deficiency in children and adolescents with obesity-A narrative review. Children (Basel) 2023; 10(4):695. DOI: https://doi.org/10.3390/children10040695
13. Stromsnes K, Correas AG, Lehmann J, Gambini J, Olaso-Gonzalez G. Anti-inflammatory properties of diet: Role in healthy aging. Biomedicines 2021; 9(8):922. DOI: https://doi.org/10.3390/biomedicines9080922
14. Gudden J, Arias Vasquez A, Bloemendaal M. The effects of intermittent fasting on brain and cognitive function. Nutrients 2021; 13(9):3166. DOI: https://doi.org/10.3390/nu13093166
15. Sandrini L, Di Minno A, Amadio P, Ieraci A, Tremoli E, Barbieri SS. Association between obesity and circulating brain-derived neurotrophic factor (BDNF) levels: Systematic review of literature and meta-analysis. Int J Mol Sci 2018; 19(8):2281. DOI: https://doi.org/10.3390/ijms19082281
16. Arida RM, Teixeira-Machado L. The contribution of physical exercise to brain resilience. Front Behav Neurosci 2021; 14:626769. DOI: https://doi.org/10.3389/fnbeh.2020.626769
17. Keawtep P, Wichayanrat W, Boripuntakul S, Chattipakorn SC, Sungkarat S. Cognitive benefits of physical exercise, physical-cognitive training, and technology-based intervention in obese individuals with and without postmenopausal condition: A narrative review. Int J Environ Res Public Health 2022; 19(20):13364. DOI: https://doi.org/10.3390/ijerph192013364
18. Stillman CM, Weinstein AM, Marsland AL, Gianaros PJ, Erickson KI. Body-brain connections: The effects of obesity and behavioral interventions on neurocognitive aging. Front Aging Neurosci 2017; 9:115. DOI: https://doi.org/10.3389/fnagi.2017.00115
19. Shao X, Tan LH, He L. Physical activity and exercise alter cognitive abilities, and brain structure and activity in obese children. Front Neurosci 2022; 16:1019129. DOI: https://doi.org/10.3389/fnins.2022.1019129
20. Davis CL, Tomporowski PD, McDowell JE, Austin BP, Miller PH, Yanasak NE, Allison JD, Naglieri JA. Exercise improves executive function and achievement and alters brain activation in overweight children: A randomized, controlled trial. Health Psychol 2011; 30(1):91-98. DOI: https://doi.org/10.1037/a0021766
21. Liu-Ambrose T, Nagamatsu LS, Graf P, Beattie BL, Ashe MC, Handy TC. Resistance training and executive functions: A 12-month randomized controlled trial. Arch Intern Med 2010; 170(2):170-178. DOI: https://doi.org/10.1001/archinternmed.2009.494
22. Villareal DT, Aguirre L, Gurney AB, Waters DL, Sinacore DR, Colombo E, Armamento-Villareal R, Qualls C. Aerobic or resistance exercise, or both, in dieting obese older adults. N Engl J Med 2017; 376(20):1943-1955. DOI: https://doi.org/10.1056/NEJMoa1616338
23. Biobaku F, Ghanim H, Monte SV, Caruana JA, Dandona P. Bariatric surgery: Remission of inflammation, cardiometabolic benefits, and common adverse effects. J Endocr Soc 2020; 4(9):bvaa049. DOI: https://doi.org/10.1210/jendso/bvaa049
24. Ionut V, Burch M, Youdim A, Bergman RN. Gastrointestinal hormones and bariatric surgery-induced weight loss. Obesity (Silver Spring) 2013; 21(6):1093-1103. DOI: https://doi.org/10.1002/oby.20364
25. Alosco ML, Galioto R, Spitznagel MB, Strain G, Devlin M, Cohen R, Crosby RD, Mitchell JE, Gunstad J. Cognitive function after bariatric surgery: evidence for improvement 3 years after surgery. Am J Surg 2014; 207(6):870-876. DOI: https://doi.org/10.1016/j.amjsurg.2013.05.018
26. Miller LA, Crosby RD, Galioto R, Strain G, Devlin MJ, Wing R, Cohen RA, Paul RH, Mitchell JE, Gunstad J. Bariatric surgery patients exhibit improved memory function 12 months postoperatively. Obes Surg 2013; 23(10):1527-1535. DOI: https://doi.org/10.1007/s11695-013-0970-7
27. Manning S, Pucci A, Batterham RL. Roux-en-Y gastric bypass: Effects on feeding behavior and underlying mechanisms. J Clin Invest. 2015; 125(3):939-948. DOI: https://doi.org/10.1172/JCI76305
28. Obregon D, Parker-Athill EC, Tan J, Murphy T. Psychotropic effects of antimicrobials and immune modulation by psychotropics: Implications for neuroimmune disorders. Neuropsychiatry (London) 2012; 2(4):331-343. DOI: https://doi.org/10.2217/npy.12.41
29. Slater D, Kunnathil S, McBride J, Koppala R. Pharmacology of nonsteroidal antiinflammatory drugs and opioids. Semin Intervent Radiol 2010; 27(4):400-411. DOI: https://doi.org/10.1055/s-0030-1267855
30. Valtonen J, Karrasch M. Polypharmacy-induced cognitive dysfunction and discontinuation of psychotropic medication: A neuropsychological case report. Ther Adv Psychopharmacol 2020; 10:2045125320905734. DOI: https://doi.org/10.1177/2045125320905734
31. Lee HW, Kim S, Jo Y, Kim Y, Ye BS, Yu YM. Neuroprotective effect of angiotensin II receptor blockers on the risk of incident Alzheimer's disease: A nationwide population-based cohort study. Front Aging Neurosci 2023; 15:1137197. DOI: https://doi.org/10.3389/fnagi.2023.1137197
32. Du MR, Gao QY, Liu CL, Bai LY, Li T, Wei FL. Exploring the pharmacological potential of metformin for neurodegenerative diseases. Front Aging Neurosci 2022; 14:838173. DOI: https://doi.org/10.3389/fnagi.2022.838173
33. Schultz BG, Patten DK, Berlau DJ. The role of statins in both cognitive impairment and protection against dementia: A tale of two mechanisms. Transl Neurodegener 2018; 7:5. DOI: https://doi.org/10.1186/s40035-018-0110-3
34. Ingersoll KS, Cohen J. The impact of medication regimen factors on adherence to chronic treatment: A review of literature. J Behav Med 2008; 31(3):213-224. DOI: https://doi.org/10.1007/s10865-007-9147-y
35. Bahar-Fuchs A, Martyr A, Goh AM, Sabates J, Clare L. Cognitive training for people with mild to moderate dementia. Cochrane Database Syst Rev 2019; 3(3):CD013069. DOI: https://doi.org/10.1002/14651858.CD013069.pub2
36. Galindo Muñoz JS, Morillas-Ruiz JM, Gómez Gallego M, Díaz Soler I, Barberá Ortega MDC, Martínez CM, Hernández Morante JJ. Cognitive training therapy improves the effect of hypocaloric treatment on subjects with overweight/obesity: A randomised clinical trial. Nutrients 2019; 11(4):925. DOI: https://doi.org/10.3390/nu11040925
37. Szabo-Reed AN, Donnelly JE. Cognitive training: Associations and implications for weight management and translational research. Transl J Am Coll Sports Med 2021; 6(2):e000151. DOI: https://doi.org/10.1249/tjx.0000000000000151
38. Wilfley DE, Kolko RP, Kass AE. Cognitive-behavioral therapy for weight management and eating disorders in children and adolescents. Child Adolesc Psychiatr Clin N Am 2011; 20(2):271-285. DOI: https://doi.org/10.1016/j.chc.2011.01.002
39. Olateju IV, Ogwu D, Owolabi MO, Azode U, Osula F, Okeke R, Akabalu I. Role of Behavioral Interventions in the Management of Obesity. Cureus 2021; 13(9):e18080. DOI: https://doi.org/10.7759/cureus.18080
40. Smith JD, Fu E, Kobayashi MA. Prevention and management of childhood obesity and its psychological and health comorbidities. Annu Rev Clin Psychol 2020; 16:351-378. DOI: https://doi.org/10.1146/annurev-clinpsy-100219-060201
41. Hegedus EJ, Moody J. Clinimetrics corner: The many faces of selection bias. J Man Manip Ther 2010; 18(2):69-73. DOI: https://doi.org/10.1179/106698110X12640740712699
42. Pannucci CJ, Wilkins EG. Identifying and avoiding bias in research. Plast Reconstr Surg 2010; 126(2):619-625. DOI: https://doi.org/10.1097/PRS.0b013e3181de24bc
43. Palinkas LA, Horwitz SM, Green CA, Wisdom JP, Duan N, Hoagwood K. Purposeful sampling for qualitative data collection and analysis in mixed method implementation research. Adm Policy Ment Health 2015; 42(5):533-544. DOI: https://doi.org/10.1007/s10488-013-0528-y
44. Shringarpure S, Xing EP. Effects of sample selection bias on the accuracy of population structure and ancestry inference. G3 (Bethesda) 2014; 4(5):901-911. DOI: https://doi.org/10.1534/g3.113.007633
45. Delaney JAC, Seeger JD. Sensitivity Analysis. In: Velentgas P, Dreyer NA, Nourjah P, et al., editors. Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Jan. Chapter 11. Available at: https://www.ncbi.nlm.nih.gov/books/NBK126178/
46. Hajat A, MacLehose RF, Rosofsky A, Walker KD, Clougherty JE. Confounding by socioeconomic status in epidemiological studies of air pollution and health: Challenges and opportunities. Environ Health Perspect 2021; 129(6):65001. DOI: https://doi.org/10.1289/EHP7980
47. Lee A, Cardel M, Donahoo WT. Social and Environmental Factors Influencing Obesity. [Updated 2019 Oct 12]. In: Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000. Available at: https://www.ncbi.nlm.nih.gov/books/NBK278977/
48. Anaika G, Regalla SS, Reddy BM, Ganguly E, Sharma PK. Association of obesity with cognitive impairment and depression among oldest old population having frailty syndrome. J Frailty Sarcopenia Falls 2022; 7(4):207-221. DOI: https://doi.org/10.22540/JFSF-07-207
49. Caruana EJ, Roman M, Hernández-Sánchez J, Solli P. Longitudinal studies. J Thorac Dis 2015; 7(11):E537-E540. DOI: https://doi.org/10.3978/j.issn.2072-1439.2015.10.63
50. Setia MS. Methodology series module 3: Cross-sectional studies. Indian J Dermatol 2016; 61(3):261-264. DOI: https://doi.org/10.4103/0019-5154.182410
51. Puhl RM, Heuer CA. Obesity stigma: Important considerations for public health. Am J Public Health 2010; 100(6):1019-1028. DOI: https://doi.org/10.2105/AJPH.2009.159491
52. Fruh SM. Obesity: Risk factors, complications, and strategies for sustainable long-term weight management. J Am Assoc Nurse Pract 2017; 29(S1):S3-S14. DOI: https://doi.org/10.1002/2327-6924.12510
53. Millum J, Campbell M, Luna F, Malekzadeh A, Karim QA. Ethical challenges in global health-related stigma research. BMC Med 2019; 17(1):84. DOI: https://doi.org/10.1186/s12916-019-1317-6
54. Nair L, Adetayo OA. Cultural competence and ethnic diversity in healthcare. Plast Reconstr Surg Glob Open 2019; 7(5):e2219. DOI: https://doi.org/10.1097/GOX.0000000000002219
55. Barrow JM, Brannan GD, Khandhar PB. Research Ethics. [Updated 2022 Sep 18]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available at: https://www.ncbi.nlm.nih.gov/books/NBK459281/
56. Kelley CP, Sbrocco G, Sbrocco T. Behavioral modification for the management of obesity. Prim Care 2016; 43(1):159-175, x. DOI: https://doi.org/10.1016/j.pop.2015.10.004
57. Peek L, Guikema S. Interdisciplinary theory, methods, and approaches for hazards and disaster research: An introduction to the special issue. Risk Anal 2021; 41(7):1047-1058. DOI: https://doi.org/10.1111/risa.13777
58. Ashikali EM, Ludwig C, Mastromauro L, Périvier S, Tholomier A, Ionita I, Graf C, Busnel C. Intrinsic capacities, functional ability, physiological systems, and caregiver support: A targeted synthesis of effective interventions and international recommendations for older adults. Int J Environ Res Public Health 2023; 20(5):4382. DOI: https://doi.org/10.3390/ijerph20054382
59. Schmitt LO, Gaspar JM. Obesity-induced brain neuroinflammatory and mitochondrial changes. Metabolites 2023; 13(1):86. DOI: https://doi.org/10.3390/metabo13010086
60. Noor J, Chaudhry A, Batool S, Noor R, Fatima G. Exploring the impact of the gut microbiome on obesity and weight loss: A review article. Cureus 2023; 15(6):e40948. DOI: https://doi.org/10.7759/cureus.40948
61. Prehn K, Profitlich T, Rangus I, Heßler S, Witte AV, Grittner U, Ordemann J, Flöel A. Bariatric surgery and brain health-A longitudinal observational study investigating the effect of surgery on cognitive function and gray matter volume. Nutrients 2020; 12(1):127. DOI: https://doi.org/10.3390/nu12010127
62. Li N, Yolton K, Lanphear BP, Chen A, Kalkwarf HJ, Braun JM. Impact of early-life weight status on cognitive abilities in children. Obesity (Silver Spring) 2018; 26(6):1088-1095. DOI: https://doi.org/10.1002/oby.22192
63. Severin R, Sabbahi A, Mahmoud AM, Arena R, Phillips SA. Precision medicine in weight loss and healthy living. Prog Cardiovasc Dis 2019; 62(1):15-20. DOI: https://doi.org/10.1016/j.pcad.2018.12.012
64. Johnson KB, Wei WQ, Weeraratne D, Frisse ME, Misulis K, Rhee K, Zhao J, Snowdon JL. Precision medicine, AI, and the future of personalized health care. Clin Transl Sci 2021; 14(1):86-93. DOI: https://doi.org/10.1111/cts.12884
65. Lövdén M, Fratiglioni L, Glymour MM, Lindenberger U, Tucker-Drob EM. Education and cognitive functioning across the life span. Psychol Sci Public Interest 2020; 21(1):6-41. DOI: https://doi.org/10.1177/1529100620920576
66. Gunstad J, Lhotsky A, Wendell CR, Ferrucci L, Zonderman AB. Longitudinal examination of obesity and cognitive function: results from the Baltimore longitudinal study of aging. Neuroepidemiology 2010; 34(4):222-229. DOI: https://doi.org/10.1159/000297742
67. National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Health Sciences Policy; Committee on Preventing Dementia and Cognitive Impairment; Downey A, Stroud C, Landis S, et al., editors. Preventing Cognitive Decline and Dementia: A Way Forward. Washington (DC): National Academies Press (US); 2017 Jun 22. 4, PRIORITIES FOR FUTURE RESEARCH. Available at: https://www.ncbi.nlm.nih.gov/books/NBK453393/
68. Kaštelan S, Braš M, Pjevač N, Bakija I, Tomić Z, Pjevač Keleminić N, Gverović Antunica A. Tear biomarkers and Alzheimer’s Disease. Int J Mol Sci 2023; 24(17):13429. DOI: https://doi.org/10.3390/ijms241713429
69. Johnson W, Deary IJ, McGue M, Christensen K. Genetic and environmental links between cognitive and physical functions in old age. J Gerontol B Psychol Sci Soc Sci 2009; 64(1):65-72. DOI: https://doi.org/10.1093/geronb/gbn033
70. Singh-Manoux A, Dugravot A, Brunner E, Kumari M, Shipley M, Elbaz A, Kivimaki M. Interleukin-6 and C-reactive protein as predictors of cognitive decline in late midlife. Neurology 2014; 83(6):486-493. DOI: https://doi.org/10.1212/WNL.0000000000000665
71. Gutch M, Kumar S, Razi SM, Gupta KK, Gupta A. Assessment of insulin sensitivity/resistance. Indian J Endocrinol Metab 2015; 19(1):160-164. DOI: https://doi.org/10.4103/2230-8210.146874
72. Salas-Venegas V, Flores-Torres RP, Rodríguez-Cortés YM, Rodríguez-Retana D, Ramírez-Carreto RJ, Concepción-Carrillo LE, Pérez-Flores LJ, Alarcón-Aguilar A, López-Díazguerrero NE, Gómez-González B, Chavarría A, Konigsberg M. The obese brain: Mechanisms of systemic and local inflammation, and interventions to reverse the cognitive deficit. Front Integr Neurosci 2022; 16:798995. DOI: https://doi.org/10.3389/fnint.2022.798995
2. Wadden TA, Tronieri JS, Butryn ML. Lifestyle modification approaches for the treatment of obesity in adults. Am Psychol 2020; 75(2):235-251. DOI: https://doi.org/10.1037/amp0000517
3. Favieri F, Forte G, Casagrande M. The executive functions in overweight and obesity: A systematic review of neuropsychological cross-sectional and longitudinal studies. Front Psychol 2019; 10:2126. DOI: https://doi.org/10.3389/fpsyg.2019.02126
4. van den Brink AC, Brouwer-Brolsma EM, Berendsen AAM, van de Rest O. The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diets are associated with less cognitive decline and a lower risk of Alzheimer's Disease - A review. Adv Nutr 2019; 10(6):1040-1065. DOI: https://doi.org/10.1093/advances/nmz054
5. Di Liegro CM, Schiera G, Proia P, Di Liegro I. Physical activity and brain health. Genes (Basel) 2019; 10(9):720. DOI: https://doi.org/10.3390/genes10090720
6. Institute of Medicine (US) Subcommittee on Military Weight Management. Weight Management: State of the Science and Opportunities for Military Programs. Washington (DC): National Academies Press (US); 2004. 4, Weight-Loss and Maintenance Strategies. Available at: https://www.ncbi.nlm.nih.gov/books/NBK221839/
7. Lindström J, Louheranta A, Mannelin M, Rastas M, Salminen V, Eriksson J, Uusitupa M, Tuomilehto J; Finnish Diabetes Prevention Study Group. The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity. Diabetes Care 2003; 26(12):3230-3236. DOI: https://doi.org/10.2337/diacare.26.12.3230
8. Sindi S, Calov E, Fokkens J, Ngandu T, Soininen H, Tuomilehto J, Kivipelto M. The CAIDE Dementia Risk Score App: The development of an evidence-based mobile application to predict the risk of dementia. Alzheimers Dement (Amst) 2015; 1(3):328-333. DOI: https://doi.org/10.1016/j.dadm.2015.06.005
9. Diabetes Prevention Program (DPP) Research Group. The Diabetes Prevention Program (DPP): Description of lifestyle intervention. Diabetes Care 2002; 25(12):2165-2171. DOI: https://doi.org/10.2337/diacare.25.12.2165
10. Kivipelto M, Solomon A, Ahtiluoto S, Ngandu T, Lehtisalo J, Antikainen R, Bäckman L, Hänninen T, Jula A, Laatikainen T, Lindström J, Mangialasche F, Nissinen A, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): Study design and progress. Alzheimers Dement 2013; 9(6):657-665. DOI: https://doi.org/10.1016/j.jalz.2012.09.012
11. Liu X, Morris MC, Dhana K, Ventrelle J, Johnson K, Bishop L, Hollings CS, Boulin A, Laranjo N, Stubbs BJ, Reilly X, Carey VJ, Wang Y, Furtado JD, Marcovina SM, Tangney C, Aggarwal NT, Arfanakis K, Sacks FM, Barnes LL. Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) study: Rationale, design and baseline characteristics of a randomized control trial of the MIND diet on cognitive decline. Contemp Clin Trials 2021; 102:106270. DOI: https://doi.org/10.1016/j.cct.2021.106270
12. Calcaterra V, Verduci E, Milanta C, Agostinelli M, Todisco CF, Bona F, Dolor J, La Mendola A, Tosi M, Zuccotti G. Micronutrient deficiency in children and adolescents with obesity-A narrative review. Children (Basel) 2023; 10(4):695. DOI: https://doi.org/10.3390/children10040695
13. Stromsnes K, Correas AG, Lehmann J, Gambini J, Olaso-Gonzalez G. Anti-inflammatory properties of diet: Role in healthy aging. Biomedicines 2021; 9(8):922. DOI: https://doi.org/10.3390/biomedicines9080922
14. Gudden J, Arias Vasquez A, Bloemendaal M. The effects of intermittent fasting on brain and cognitive function. Nutrients 2021; 13(9):3166. DOI: https://doi.org/10.3390/nu13093166
15. Sandrini L, Di Minno A, Amadio P, Ieraci A, Tremoli E, Barbieri SS. Association between obesity and circulating brain-derived neurotrophic factor (BDNF) levels: Systematic review of literature and meta-analysis. Int J Mol Sci 2018; 19(8):2281. DOI: https://doi.org/10.3390/ijms19082281
16. Arida RM, Teixeira-Machado L. The contribution of physical exercise to brain resilience. Front Behav Neurosci 2021; 14:626769. DOI: https://doi.org/10.3389/fnbeh.2020.626769
17. Keawtep P, Wichayanrat W, Boripuntakul S, Chattipakorn SC, Sungkarat S. Cognitive benefits of physical exercise, physical-cognitive training, and technology-based intervention in obese individuals with and without postmenopausal condition: A narrative review. Int J Environ Res Public Health 2022; 19(20):13364. DOI: https://doi.org/10.3390/ijerph192013364
18. Stillman CM, Weinstein AM, Marsland AL, Gianaros PJ, Erickson KI. Body-brain connections: The effects of obesity and behavioral interventions on neurocognitive aging. Front Aging Neurosci 2017; 9:115. DOI: https://doi.org/10.3389/fnagi.2017.00115
19. Shao X, Tan LH, He L. Physical activity and exercise alter cognitive abilities, and brain structure and activity in obese children. Front Neurosci 2022; 16:1019129. DOI: https://doi.org/10.3389/fnins.2022.1019129
20. Davis CL, Tomporowski PD, McDowell JE, Austin BP, Miller PH, Yanasak NE, Allison JD, Naglieri JA. Exercise improves executive function and achievement and alters brain activation in overweight children: A randomized, controlled trial. Health Psychol 2011; 30(1):91-98. DOI: https://doi.org/10.1037/a0021766
21. Liu-Ambrose T, Nagamatsu LS, Graf P, Beattie BL, Ashe MC, Handy TC. Resistance training and executive functions: A 12-month randomized controlled trial. Arch Intern Med 2010; 170(2):170-178. DOI: https://doi.org/10.1001/archinternmed.2009.494
22. Villareal DT, Aguirre L, Gurney AB, Waters DL, Sinacore DR, Colombo E, Armamento-Villareal R, Qualls C. Aerobic or resistance exercise, or both, in dieting obese older adults. N Engl J Med 2017; 376(20):1943-1955. DOI: https://doi.org/10.1056/NEJMoa1616338
23. Biobaku F, Ghanim H, Monte SV, Caruana JA, Dandona P. Bariatric surgery: Remission of inflammation, cardiometabolic benefits, and common adverse effects. J Endocr Soc 2020; 4(9):bvaa049. DOI: https://doi.org/10.1210/jendso/bvaa049
24. Ionut V, Burch M, Youdim A, Bergman RN. Gastrointestinal hormones and bariatric surgery-induced weight loss. Obesity (Silver Spring) 2013; 21(6):1093-1103. DOI: https://doi.org/10.1002/oby.20364
25. Alosco ML, Galioto R, Spitznagel MB, Strain G, Devlin M, Cohen R, Crosby RD, Mitchell JE, Gunstad J. Cognitive function after bariatric surgery: evidence for improvement 3 years after surgery. Am J Surg 2014; 207(6):870-876. DOI: https://doi.org/10.1016/j.amjsurg.2013.05.018
26. Miller LA, Crosby RD, Galioto R, Strain G, Devlin MJ, Wing R, Cohen RA, Paul RH, Mitchell JE, Gunstad J. Bariatric surgery patients exhibit improved memory function 12 months postoperatively. Obes Surg 2013; 23(10):1527-1535. DOI: https://doi.org/10.1007/s11695-013-0970-7
27. Manning S, Pucci A, Batterham RL. Roux-en-Y gastric bypass: Effects on feeding behavior and underlying mechanisms. J Clin Invest. 2015; 125(3):939-948. DOI: https://doi.org/10.1172/JCI76305
28. Obregon D, Parker-Athill EC, Tan J, Murphy T. Psychotropic effects of antimicrobials and immune modulation by psychotropics: Implications for neuroimmune disorders. Neuropsychiatry (London) 2012; 2(4):331-343. DOI: https://doi.org/10.2217/npy.12.41
29. Slater D, Kunnathil S, McBride J, Koppala R. Pharmacology of nonsteroidal antiinflammatory drugs and opioids. Semin Intervent Radiol 2010; 27(4):400-411. DOI: https://doi.org/10.1055/s-0030-1267855
30. Valtonen J, Karrasch M. Polypharmacy-induced cognitive dysfunction and discontinuation of psychotropic medication: A neuropsychological case report. Ther Adv Psychopharmacol 2020; 10:2045125320905734. DOI: https://doi.org/10.1177/2045125320905734
31. Lee HW, Kim S, Jo Y, Kim Y, Ye BS, Yu YM. Neuroprotective effect of angiotensin II receptor blockers on the risk of incident Alzheimer's disease: A nationwide population-based cohort study. Front Aging Neurosci 2023; 15:1137197. DOI: https://doi.org/10.3389/fnagi.2023.1137197
32. Du MR, Gao QY, Liu CL, Bai LY, Li T, Wei FL. Exploring the pharmacological potential of metformin for neurodegenerative diseases. Front Aging Neurosci 2022; 14:838173. DOI: https://doi.org/10.3389/fnagi.2022.838173
33. Schultz BG, Patten DK, Berlau DJ. The role of statins in both cognitive impairment and protection against dementia: A tale of two mechanisms. Transl Neurodegener 2018; 7:5. DOI: https://doi.org/10.1186/s40035-018-0110-3
34. Ingersoll KS, Cohen J. The impact of medication regimen factors on adherence to chronic treatment: A review of literature. J Behav Med 2008; 31(3):213-224. DOI: https://doi.org/10.1007/s10865-007-9147-y
35. Bahar-Fuchs A, Martyr A, Goh AM, Sabates J, Clare L. Cognitive training for people with mild to moderate dementia. Cochrane Database Syst Rev 2019; 3(3):CD013069. DOI: https://doi.org/10.1002/14651858.CD013069.pub2
36. Galindo Muñoz JS, Morillas-Ruiz JM, Gómez Gallego M, Díaz Soler I, Barberá Ortega MDC, Martínez CM, Hernández Morante JJ. Cognitive training therapy improves the effect of hypocaloric treatment on subjects with overweight/obesity: A randomised clinical trial. Nutrients 2019; 11(4):925. DOI: https://doi.org/10.3390/nu11040925
37. Szabo-Reed AN, Donnelly JE. Cognitive training: Associations and implications for weight management and translational research. Transl J Am Coll Sports Med 2021; 6(2):e000151. DOI: https://doi.org/10.1249/tjx.0000000000000151
38. Wilfley DE, Kolko RP, Kass AE. Cognitive-behavioral therapy for weight management and eating disorders in children and adolescents. Child Adolesc Psychiatr Clin N Am 2011; 20(2):271-285. DOI: https://doi.org/10.1016/j.chc.2011.01.002
39. Olateju IV, Ogwu D, Owolabi MO, Azode U, Osula F, Okeke R, Akabalu I. Role of Behavioral Interventions in the Management of Obesity. Cureus 2021; 13(9):e18080. DOI: https://doi.org/10.7759/cureus.18080
40. Smith JD, Fu E, Kobayashi MA. Prevention and management of childhood obesity and its psychological and health comorbidities. Annu Rev Clin Psychol 2020; 16:351-378. DOI: https://doi.org/10.1146/annurev-clinpsy-100219-060201
41. Hegedus EJ, Moody J. Clinimetrics corner: The many faces of selection bias. J Man Manip Ther 2010; 18(2):69-73. DOI: https://doi.org/10.1179/106698110X12640740712699
42. Pannucci CJ, Wilkins EG. Identifying and avoiding bias in research. Plast Reconstr Surg 2010; 126(2):619-625. DOI: https://doi.org/10.1097/PRS.0b013e3181de24bc
43. Palinkas LA, Horwitz SM, Green CA, Wisdom JP, Duan N, Hoagwood K. Purposeful sampling for qualitative data collection and analysis in mixed method implementation research. Adm Policy Ment Health 2015; 42(5):533-544. DOI: https://doi.org/10.1007/s10488-013-0528-y
44. Shringarpure S, Xing EP. Effects of sample selection bias on the accuracy of population structure and ancestry inference. G3 (Bethesda) 2014; 4(5):901-911. DOI: https://doi.org/10.1534/g3.113.007633
45. Delaney JAC, Seeger JD. Sensitivity Analysis. In: Velentgas P, Dreyer NA, Nourjah P, et al., editors. Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Jan. Chapter 11. Available at: https://www.ncbi.nlm.nih.gov/books/NBK126178/
46. Hajat A, MacLehose RF, Rosofsky A, Walker KD, Clougherty JE. Confounding by socioeconomic status in epidemiological studies of air pollution and health: Challenges and opportunities. Environ Health Perspect 2021; 129(6):65001. DOI: https://doi.org/10.1289/EHP7980
47. Lee A, Cardel M, Donahoo WT. Social and Environmental Factors Influencing Obesity. [Updated 2019 Oct 12]. In: Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000. Available at: https://www.ncbi.nlm.nih.gov/books/NBK278977/
48. Anaika G, Regalla SS, Reddy BM, Ganguly E, Sharma PK. Association of obesity with cognitive impairment and depression among oldest old population having frailty syndrome. J Frailty Sarcopenia Falls 2022; 7(4):207-221. DOI: https://doi.org/10.22540/JFSF-07-207
49. Caruana EJ, Roman M, Hernández-Sánchez J, Solli P. Longitudinal studies. J Thorac Dis 2015; 7(11):E537-E540. DOI: https://doi.org/10.3978/j.issn.2072-1439.2015.10.63
50. Setia MS. Methodology series module 3: Cross-sectional studies. Indian J Dermatol 2016; 61(3):261-264. DOI: https://doi.org/10.4103/0019-5154.182410
51. Puhl RM, Heuer CA. Obesity stigma: Important considerations for public health. Am J Public Health 2010; 100(6):1019-1028. DOI: https://doi.org/10.2105/AJPH.2009.159491
52. Fruh SM. Obesity: Risk factors, complications, and strategies for sustainable long-term weight management. J Am Assoc Nurse Pract 2017; 29(S1):S3-S14. DOI: https://doi.org/10.1002/2327-6924.12510
53. Millum J, Campbell M, Luna F, Malekzadeh A, Karim QA. Ethical challenges in global health-related stigma research. BMC Med 2019; 17(1):84. DOI: https://doi.org/10.1186/s12916-019-1317-6
54. Nair L, Adetayo OA. Cultural competence and ethnic diversity in healthcare. Plast Reconstr Surg Glob Open 2019; 7(5):e2219. DOI: https://doi.org/10.1097/GOX.0000000000002219
55. Barrow JM, Brannan GD, Khandhar PB. Research Ethics. [Updated 2022 Sep 18]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available at: https://www.ncbi.nlm.nih.gov/books/NBK459281/
56. Kelley CP, Sbrocco G, Sbrocco T. Behavioral modification for the management of obesity. Prim Care 2016; 43(1):159-175, x. DOI: https://doi.org/10.1016/j.pop.2015.10.004
57. Peek L, Guikema S. Interdisciplinary theory, methods, and approaches for hazards and disaster research: An introduction to the special issue. Risk Anal 2021; 41(7):1047-1058. DOI: https://doi.org/10.1111/risa.13777
58. Ashikali EM, Ludwig C, Mastromauro L, Périvier S, Tholomier A, Ionita I, Graf C, Busnel C. Intrinsic capacities, functional ability, physiological systems, and caregiver support: A targeted synthesis of effective interventions and international recommendations for older adults. Int J Environ Res Public Health 2023; 20(5):4382. DOI: https://doi.org/10.3390/ijerph20054382
59. Schmitt LO, Gaspar JM. Obesity-induced brain neuroinflammatory and mitochondrial changes. Metabolites 2023; 13(1):86. DOI: https://doi.org/10.3390/metabo13010086
60. Noor J, Chaudhry A, Batool S, Noor R, Fatima G. Exploring the impact of the gut microbiome on obesity and weight loss: A review article. Cureus 2023; 15(6):e40948. DOI: https://doi.org/10.7759/cureus.40948
61. Prehn K, Profitlich T, Rangus I, Heßler S, Witte AV, Grittner U, Ordemann J, Flöel A. Bariatric surgery and brain health-A longitudinal observational study investigating the effect of surgery on cognitive function and gray matter volume. Nutrients 2020; 12(1):127. DOI: https://doi.org/10.3390/nu12010127
62. Li N, Yolton K, Lanphear BP, Chen A, Kalkwarf HJ, Braun JM. Impact of early-life weight status on cognitive abilities in children. Obesity (Silver Spring) 2018; 26(6):1088-1095. DOI: https://doi.org/10.1002/oby.22192
63. Severin R, Sabbahi A, Mahmoud AM, Arena R, Phillips SA. Precision medicine in weight loss and healthy living. Prog Cardiovasc Dis 2019; 62(1):15-20. DOI: https://doi.org/10.1016/j.pcad.2018.12.012
64. Johnson KB, Wei WQ, Weeraratne D, Frisse ME, Misulis K, Rhee K, Zhao J, Snowdon JL. Precision medicine, AI, and the future of personalized health care. Clin Transl Sci 2021; 14(1):86-93. DOI: https://doi.org/10.1111/cts.12884
65. Lövdén M, Fratiglioni L, Glymour MM, Lindenberger U, Tucker-Drob EM. Education and cognitive functioning across the life span. Psychol Sci Public Interest 2020; 21(1):6-41. DOI: https://doi.org/10.1177/1529100620920576
66. Gunstad J, Lhotsky A, Wendell CR, Ferrucci L, Zonderman AB. Longitudinal examination of obesity and cognitive function: results from the Baltimore longitudinal study of aging. Neuroepidemiology 2010; 34(4):222-229. DOI: https://doi.org/10.1159/000297742
67. National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Health Sciences Policy; Committee on Preventing Dementia and Cognitive Impairment; Downey A, Stroud C, Landis S, et al., editors. Preventing Cognitive Decline and Dementia: A Way Forward. Washington (DC): National Academies Press (US); 2017 Jun 22. 4, PRIORITIES FOR FUTURE RESEARCH. Available at: https://www.ncbi.nlm.nih.gov/books/NBK453393/
68. Kaštelan S, Braš M, Pjevač N, Bakija I, Tomić Z, Pjevač Keleminić N, Gverović Antunica A. Tear biomarkers and Alzheimer’s Disease. Int J Mol Sci 2023; 24(17):13429. DOI: https://doi.org/10.3390/ijms241713429
69. Johnson W, Deary IJ, McGue M, Christensen K. Genetic and environmental links between cognitive and physical functions in old age. J Gerontol B Psychol Sci Soc Sci 2009; 64(1):65-72. DOI: https://doi.org/10.1093/geronb/gbn033
70. Singh-Manoux A, Dugravot A, Brunner E, Kumari M, Shipley M, Elbaz A, Kivimaki M. Interleukin-6 and C-reactive protein as predictors of cognitive decline in late midlife. Neurology 2014; 83(6):486-493. DOI: https://doi.org/10.1212/WNL.0000000000000665
71. Gutch M, Kumar S, Razi SM, Gupta KK, Gupta A. Assessment of insulin sensitivity/resistance. Indian J Endocrinol Metab 2015; 19(1):160-164. DOI: https://doi.org/10.4103/2230-8210.146874
72. Salas-Venegas V, Flores-Torres RP, Rodríguez-Cortés YM, Rodríguez-Retana D, Ramírez-Carreto RJ, Concepción-Carrillo LE, Pérez-Flores LJ, Alarcón-Aguilar A, López-Díazguerrero NE, Gómez-González B, Chavarría A, Konigsberg M. The obese brain: Mechanisms of systemic and local inflammation, and interventions to reverse the cognitive deficit. Front Integr Neurosci 2022; 16:798995. DOI: https://doi.org/10.3389/fnint.2022.798995
How to Cite
Callaghan, R. (2023). A Comprehensive Review on the Role of Obesity in Functional Cognition (Part III): Risk Factors and Studying Challenges. Science Insights, 43(3), 1059–1071. https://doi.org/10.15354/si.23.re709
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